Ullmann, Enrico and Perry, Seth W. and Licinio, Julio and Wong, Ma-Li and Dremencov, Eliyahu and Zavjalov, Evgenii L. and Shevelev, Oleg B. and Khotskin, Nikita V. and Koncevaya, Galina V. and Khotshkina, Anna S. and Moshkin, Mikhail P. and Lapshin, Maxim S. and Komelkova, Maria V. and Feklicheva, Inna V. and Tseilikman, Olga B. and Cherkasova, Olga P. and Bhui, Kamaldeep S. and Jones, Edgar and Kirschbaum, Clemens and Bornstein, Stefan R. and Tseilikman, Vadim (2019) From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? Frontiers in Behavioral Neuroscience, 13. ISSN 1662-5153
![[thumbnail of pubmed-zip/versions/3/package-entries/fnbeh-13-00047-r2/fnbeh-13-00047.pdf]](http://science.oadigitallibraries.com/style/images/fileicons/text.png)
Text
pubmed-zip/versions/3/package-entries/fnbeh-13-00047-r2/fnbeh-13-00047.pdf - Published Version
Download (1MB)
Abstract
The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed.
| Item Type: | Article |
|---|---|
| Subjects: | Academics Guard > Biological Science |
| Depositing User: | Unnamed user with email support@academicsguard.com |
| Date Deposited: | 14 Feb 2023 11:09 |
| Last Modified: | 29 Jun 2024 12:43 |
| URI: | http://science.oadigitallibraries.com/id/eprint/111 |
Actions (login required)
- View Item