Assessment of Some Biochemical Parameters in Iraqi Pregnant Women with and Without Complications

Aims: The purpose of this study was to evaluate and compare some biochemical parameters including [ceruloplasmin oxidase(CP), α – fetoprotein (AFP), interleukine-1 (IL-1), α2- macroglobulin (α2 – MG), α1 antitrypsin(α1 – AT)] and β-human gonadotropin(β -HCG)] in Iraqi women with pregnant complications ( mole ,ectopic and missed abortion ) compared with normal pregnant women .

Study Design: This is a case-control study which included 63 women with pregnant complications (25 with missed abortion having - mean age 26.68 ± 7.54 yrs, 21 with mole having - mean age 26.14± 8.19 yrs and 17 having ectopic - mean age 26.14 ± 6.99 yrs) pregnancy and 25 normal pregnancy women with mean age 25.16 ± 5.97 yrs as control.

Place and Duration of Study: Samples collected from the Baghdad Medical City, AL-Yarmook and Fatema AL-Zahraa hospitals during the period from September 2011 to April 2012.

Methodology: Alpha feto protein, IL- 1, α2 – MG, α1 – AT and β -hCG were measured by immunoassay method. CP activity was measured using the modified Rice method.

Results: AFP and IL-1 were significantly decreased (p≤ 0.05) in all patients groups but Cp, activity was decreased significantly only in EP and MP groups (p≤ 0.05). There was a significantly increased (p≤ 0.05) in β-hCG level in mole or missed abortion and significantly decreased (p≤ 0.05) in ectopic pregnancy compared with controls. α2-MG levels were significantly increased in EP , MP compared to control.α1-AT were elevated significantly (p≤ 0.05) in all women with pregnancy complications compared with controls.In mole pregnancy there were positive correlation between α2 – MG with β-hCG (r= 0.51, p= 0.01) or with α1 – AT (r= 0.49, p= 0.02) and negative correlation between AFP with α1 – AT (r= - 0.41, p= 0.05), IL- 1 with α2 – MG(r= - 0.44, p= 0.04). CP positively correlated with IL- 1 (r= 0.734, p= 0.00) while in missed abortion there were positive correlations between β-hCG and AFP (r= 0.42, p= 0.034), IL-1α (r = 0.83, p= 0.00) with α2-MG (r = 0.060, p= 0.00) and between AFP with α2-MG (r = 0.45, p= 0.02) and between IL- 1 with α2-MG (r = 0.75, p= 0.00).

Conclusion: This study shows that the above biological parameters could be used for the monitoring the health status of pregnant women with complications.