Genetic and Epigenetic Studies in Diabetic Kidney Disease

Gu, Harvest F. (2019) Genetic and Epigenetic Studies in Diabetic Kidney Disease. Frontiers in Genetics, 10. ISSN 1664-8021

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Abstract

Chronic kidney disease is a worldwide health crisis, while diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease (ESRD). DKD is a microvascular complication and occurs in 30–40% of diabetes patients. Epidemiological investigations and clinical observations on the familial clustering and heritability in DKD have highlighted an underlying genetic susceptibility. Furthermore, DKD is a progressive and long-term diabetic complication, in which epigenetic effects and environmental factors interact with an individual’s genetic background. In recent years, researchers have undertaken genetic and epigenetic studies of DKD in order to better understand its molecular mechanisms. In this review, clinical material, research approaches and experimental designs that have been used for genetic and epigenetic studies of DKD are described. Current information from genetic and epigenetic studies of DKD and ESRD in patients with diabetes, including the approaches of genome-wide association study (GWAS) or epigenome-wide association study (EWAS) and candidate gene association analyses, are summarized. Further investigation of molecular defects in DKD with new approaches such as next generation sequencing analysis and phenome-wide association study (PheWAS) is also discussed.

Item Type: Article
Subjects: Academics Guard > Medical Science
Depositing User: Unnamed user with email support@academicsguard.com
Date Deposited: 21 Feb 2023 10:24
Last Modified: 01 Jul 2024 13:36
URI: http://science.oadigitallibraries.com/id/eprint/196

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