Study of the Biological Activity of Alkyl Derivatives of Tetrahydroisoquinolines

Khamidova, Umida and Terenteva, Ekaterina and Umarova, Mukaddas and Abdurakhmanov, Jaloliddin and Sasmakov, Sabirdjan and Makhnyov, Artyom and Vinogradova, Valentina and Saidov, Abdusalom and Khashimova, Zaynat and Azimova, Shakhnoz (2021) Study of the Biological Activity of Alkyl Derivatives of Tetrahydroisoquinolines. Journal of Pharmaceutical Research International, 33 (46B). pp. 238-246. ISSN 2456-9119

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Official URL: https://doi.org/10.9734/jpri/2021/v33i46B32938

Abstract

A row of 1-alkyne (C6-C17) derivatives against tetrahydroisoquinoline have been synthesized. 1-alkyne (C6-C17) derivatives cytotoxicity against three lines of cancer cells and two lines of normal cells was studied. It was found that 1-tridecyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline exhibits a high cytotoxic effect with low toxicity to healthy cells. Antimicrobial activity of 1-alkyne (C6-C17) derivatives against 5 strains of bacteria and fungus was studied. It has been found that 1-nonyl-6,7-dimethoxy-1,3,4-tetrahydroisoquinoline exhibits strong antibacterial and antifungal effects.

Item Type:	Article
Subjects:	Academics Guard > Medical Science
Depositing User:	Unnamed user with email support@academicsguard.com
Date Deposited:	30 Jan 2023 11:04
Last Modified:	02 May 2024 06:26
URI:	http://science.oadigitallibraries.com/id/eprint/6

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